The High Gravity Controlled Precipitation (HGCP) technology platform was developed based on fundamental mass transfer principles wherein micro mixing of the reaction phases is achieved in microseconds, with the reaction phases brought together under a high gravity environment. In a precipitation process, a high degree of super-saturation, uniform spatial concentration distributions and identical growth time for all crystals are essential conditions for the syntheses of nano-particles with narrow size distribution. In view of the fact that mass transfer rate and micro-mixing is much larger in our HGCP reactor than that in a conventional reactor, due to the high gravity environment, this facilitates the generation of higher supersaturated concentrations of the product in the precipitation process. Therefore, the HGCP technology is an ideal platform technology through which a wide range of nano-sized medicines can be developed and synthesized.
Advantages of the HGCP technology platform are:
- Scalability: Cost effective scale up for large scale production of nano-medicines
- Control: Good control over quality, particle size and distribution, particle shape and morphology, and stability of the nano-medicines
- Versatility: Can be used for different nano-medicines synthesis
- Reduce Time: The “crystallization, micronization and conditioning” processes can be consolidated into one-step process